Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
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RBRC No. RBRC05667  
Type Transgene CongenicCartagena  
Species Mus musculus  
Strain name B10.Cg-H2<k> Tg(H2-Ea-Cd74/MCC)37GNnak  
Former Common name Ii-MCC, B10.BR-Ii-MCC Tg#37  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Naoko Nakano, Institute of Genetics and Molecular and Cellular Biology in 1996. Transgene was injected into the pronuclei of (C57BL/6 x SJL) F2 fertilized eggs. The mice were backcrossed to B10.BR over 10 times.  
Strain description Ii-MCC transgenic mice expressing a fusion protein of Cd74 (MHC II invariant chain) and sequence encoding 88-103 peptides of moth cytochrome c (MCC).  
Colony maintenance Carrier x Noncarrier [or Crossing to B10.BR/SgSnSlc]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol H2  
Symbol name histocompatibility-2, MHC  
Chromosome 17  
Common name No Data  
Symbol description No Data  
 2 Symbol MCC  
Symbol name Moth cytochrome C  
Chromosome UN  
Common name No Data  
Symbol description No Data  
 3 Symbol Tg(H2-Ea-Cd74/MCC)37GNnak  
Symbol name No Data  
Chromosome UN  
Common name No Data  
Symbol description No Data  
Promoter mouse MHC class II E alpha promoter  
 4 Symbol Cd74  
Symbol name CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
References
  

Research applications Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Int. Immunol., 14, 857-865 (2002).  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Nakano, Naoko (Tokyo university of science)  Nakano, Naoko 
Strain Status /
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