Strain Information | |
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Image | |
BRC No. | RBRC05713 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129S7-Asgr1<tm1Ishi>/Tats |
Former Common name | Asgr1 KO |
H-2 Haplotype | |
ES Cell line | JH1 [129S7/SvEvBrd] |
Background strain | |
Appearance | |
Strain development | Developed by Shun Ishibashi, Faculty of Medicine, University of Tokyo in 2001. JH1 ES cells derived from 129S7/SvEvBrd were used for the generation of knockout mice. The mice were backcrossed to C57BL/6J for 8 generations by Laboratory of Cancer Biology and Molecular Immunology, University of Tokyo. |
Strain description | Asgr1 knockout mice. The transcription initiation codon and the sequences encoding the transmembrane domain of Asgr1 gene were replaced with a pol2neo cassette. Homozygous mice show an impaired hepatic clearance of asialoglycoproteins. |
Colony maintenance | Heterozygote x Wild-type [C57BL/6JJcl] |
References | J. Biol. Chem., 276, 12624-12628 (2001). 11278827 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter |
Ordering Information | |
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Donor DNA | E. coli Neomycin resistance gene, Mouse Asgr1 genomic DNA, bovine Growth hormone polyA, Mouse RNA polymerase II promoter |
Research application | Cell Biology Research Metabolism Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 276, 12624-12628 (2001).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
Depositor | Tatsuro Irimura (The University of Tokyo) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |