Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
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RBRC No. RBRC05713  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129S7-Asgr1<tm1Ishi>/Tats  
Former Common name Asgr1 KO  
H-2 Haplotype No Data  
ES cell line JH1 [129S7/SvEvBrd]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Shun Ishibashi, Faculty of Medicine, University of Tokyo in 2001. JH1 ES cells derived from 129S7/SvEvBrd were used for the generation of knockout mice. The mice were backcrossed to C57BL/6J for 8 generations by Laboratory of Cancer Biology and Molecular Immunology, University of Tokyo.  
Strain description Asgr1 knockout mice. The transcription initiation codon and the sequences encoding the transmembrane domain of Asgr1 gene were replaced with a pol2neo cassette. Homozygous mice show an impaired hepatic clearance of asialoglycoproteins.  
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Asgr1  
Symbol name asialoglycoprotein receptor 1  
Chromosome 11  
Common name No Data  
Symbol description No Data  
References   
Research applications Cell Biology Research,
Metabolism Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Biol. Chem., 276, 12624-12628 (2001).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.  
Additional information
 1 No Data  
Depositor Irimura, Tatsuro (The University of Tokyo)  Irimura, Tatsuro 
Strain Status /
Availability
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