Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Aug 20, 2019
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RBRC No. RBRC05754  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129P2-Map3k6<tm1Hijo>  
Former Common name ASK2 KO, B6-Map3k6 KO  
H-2 Haplotype No Data  
ES cell line E14 [129P2/OlaHsd]  
Background strain C57BL/6JJcl  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Hidenori Ichijo, Graduate School of Pharmaceutical Sciences, The University of Tokyo in 2009. E14 ES cells were used. The mutant mice are backcrossed to C57BL/6J.  
Strain description Map3k6 gene knockout mice. The exons 1 to 5 were replaced with a NLS-lacZ cassette and a pgk-neo cassette.  
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6JJcl] Homozygous mutant mice are viable and fertile.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Map3k6  
Symbol name mitogen-activated protein kinase kinase kinase 6  
Chromosome 4  
Common name No Data  
Symbol description No Data  
 2 Symbol lacZ  
Symbol name beta-galactosidase (E. coli)  
Chromosome 4  
Common name No Data  
Symbol description No Data  
 3 Symbol nls  
Symbol name SV40 large T antigen nuclear localization signal (NLS)  
Chromosome 4  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 4 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 4  
Common name neo; neomycin;  
Symbol description No Data  
References J Biol Chem. 2007 Jan 8;.
  
Apoptosis signal-regulating kinase 2 (ASK2) functions as a MAP3K in a heteromeric complex with ASK1.
Apoptosis signal-regulating kinase 2 (ASK2) functions as a MAP3K in a heteromeric complex with ASK1.
Research applications Fluorescent Proteins/lacZ System,
Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
Depositor Ichijo, Hidenori (The University of Tokyo)  Ichijo, Hidenori 
Strain Status /
Availability
(Expected delivery)

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