Strain Information | |
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Image | |
BRC No. | RBRC05758 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.Cg-Spred1<tm1Hiin> |
Former Common name | Spred1 KO, B6-Spred1 KO |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Akihiko Yoshimura, Medical Institute of Bioregulation, Kyushu University. |
Strain description | Spred1 gene knockout mice. Most of exon 4 was replaced with a PGK-neo cassette. Homozygous mutant mice exhibit impaired spatial learning and memory, shortened head and kinked tail, and abnormal eosinophil physiology and increased airway responsiveness. |
Colony maintenance | Heterozygote x Wild-type [C57BL/6JJcl] |
References | J. Exp. Med., 201, 73-82 (2005). 15630138 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Spred1sprouty protein with EVH-1 domain 1, related sequence2Spred1<tm1Hiin>targeted mutation 1, Hiromasa Inoue Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)2mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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Donor DNA | Mouse Phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene, Mouse Spred1 genomic DNA |
Research application | Developmental Biology Research Neurobiology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Exp. Med., 201, 73-82 (2005).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
Depositor | Akihiko Yoshimura (Keio University) |
Strain Status | Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |