Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
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RBRC No. RBRC05765  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.Cg-H2az1<tm1.1Hko> H2az2<tm1.1Hko>  
Former Common name H2AZ1/2 floxed, B6-H2AZ1/2 floxed  
H-2 Haplotype No Data  
ES cell line M1 [(C57BL/6 x 129)F1]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Dr. Haruhiko Koseki, RIKEN Center for Allergy and Immunology in 2009. M1 ES cells derived from (C57BL/6 x 129) F1 were used. The mutant mice were crossed to C57BL/6J. Neomycin resistant genes were removed.  
Strain description H2A.Z1 and Z2 floxed mice. Histone variant H2A.Z (H2afz) gene is required for mammalian development.  
Colony maintenance H2afz : Homozygote x Homozygote ; H2afv : Homozygote x Homozygote [or Crossing to C57BL/6JJcl]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Frt  
Symbol name yeast FRT (flippase recombination target) site  
Chromosome 11  
Common name No Data  
Symbol description No Data  
 2 Symbol H2afv  
Symbol name H2A histone family, member V  
Chromosome 11  
Common name No Data  
Symbol description No Data  
 3 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 11  
Common name No Data  
Symbol description No Data  
 4 Symbol Frt  
Symbol name yeast FRT (flippase recombination target) site  
Chromosome 3  
Common name No Data  
Symbol description No Data  
 5 Symbol H2afz  
Symbol name H2A histone family, member Z  
Chromosome 3  
Common name No Data  
Symbol description No Data  
 6 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 3  
Common name No Data  
Symbol description No Data  
References   
Research applications Cre/loxP system,
FLP/frt system  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Koseki, Haruhiko (RIKEN Research Center For Allergy and Immunology)  Koseki, Haruhiko 
Strain Status /
Availability
(Expected delivery)

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