Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Aug 20, 2019
Health Report   PCR Protocol   Thawing Method
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RBRC No. RBRC05892  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129P2-Reck<tm1Ito>/Noda  
Former Common name Recktm1(neo)Noda, global Reck knockout  
H-2 Haplotype No Data  
ES cell line E14 [129P2/OlaHsd]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Chiaki Tkahashi, Regina M. Sasahara, Junseo Oh, Kyoto University Graduate School of Medicine, Shigeyoshi Itohara, RIKEN Brain Research Institute. E14 ES cells were used. The mutant mice were crossed to C57BL/6.  
Strain description Reck gene knockout mice. Exon 1 of the Reck gene was replaced with a PGK-neo cassette. Homozygous mutant mice die around E10.5 with defects in collagen fibrils, basal lamina and vascular development.  
Colony maintenance Heterozygote x Wild-type [C57BL/6JJmsSlc] Homozygous mutant mice are embryonic lethal.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Reck  
Symbol name reversion-inducing-cysteine-rich protein with kazal motifs  
Chromosome 4  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 4  
Common name No Data  
Symbol description No Data  
References Nat Neurosci. 2007 Jul;10(7):838-45. Epub 2007 Jun 10.
  
RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity.
RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity.
Research applications Neurobiology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Cell, 107, 789-800 (2001).
1. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an
acknowledgment to the DEPOSITOR is requested.
2. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.
3. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT shall obtain approval from the DEPOSITOR using the Approval Form.
4. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT shall reach agreement on terms and conditions of use of it with DEPOSITOR and shall obtain a prior written consent from the DEPOSITOR.
5. The RECIPIENT shall contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Noda, Makoto (Graduate School of Medicine, Kyoto University)  Noda, Makoto 
Strain Status /
Availability
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