Strain Data Sheet
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Data update: Jul 19, 2019
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RBRC No. RBRC05911  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129S6-Cd109<tm1Mat>  
Former Common name CD109-KO  
H-2 Haplotype No Data  
ES cell line CSL3[129S6/SvEvTac]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Shinji Mii and Masahide Takahashi, Nagoya University Graduate School of Medicine in 2008. CSL3 ES cells derived from 129S6 were used. The mutant mice were backcrossed to C57BL/6J over 10 times.  
Strain description CD109 gene knockout mice. Part of exon 1 and all of exon 2 of the Cd109 gene were replaced with lacZ and PGK-neo cassettes. Homozygous mutant mice show abnormal hair growth, epidermal hyperplasia and thickening, sebaceous gland hyperplasia at P7.  
Colony maintenance Heterozygote x Wild-type [C57BL/6JJmsSlc]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol No Data  
Symbol name Human beta-globin polyA  
Chromosome 9  
Common name No Data  
Symbol description No Data  
 2 Symbol Cd109  
Symbol name CD109 antigen  
Chromosome 9  
Common name No Data  
Symbol description No Data  
 3 Symbol lacZ  
Symbol name beta-galactosidase (E. coli)  
Chromosome 9  
Common name No Data  
Symbol description No Data  
 4 Symbol nls  
Symbol name SV40 large T antigen nuclear localization signal (NLS)  
Chromosome 9  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 5 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 9  
Common name No Data  
Symbol description No Data  
References   
Research applications Cancer Research,
Dermatology Research,
Developmental Biology Research,
Fluorescent Proteins/lacZ System  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Am. J. Pathol., 181, 1180-1189 (2012 ).
The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 Mouse of the Month Nov 2013  
 2 Genotyping protocol <PCR>  
Depositor Takahashi, Masahide (Nagoya University)  Takahashi, Masahide 
Strain Status /
Availability
(Expected delivery)

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