Strain Data Sheet
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Data update: Jul 19, 2019
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RBRC No. RBRC05943  
Type TransgeneCartagena  
Species Mus musculus  
Strain name B6.Cg-Tg(Mt1-RET)242Ina Tg(Dct-LacZ)A12Jkn  
Former Common name 242RET;Dct-LacZ  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Masashi Kato, Nagoya University Graduate School of Medicine. Generated by crossing of RET mice and Hr mice (Hos:HRM). The mice were backcrossed to C57BL/6 over 10 times.  
Strain description Mt1-RET/Dct-lacZ Tg mice. These mice express the lacZ in melanocytes under the control of Dct promoter and the human RET under the control of the mouse MT1 promoter/enhancer. Mt1-RET homozygous mutant mice are embryonic lethal.  
Colony maintenance Mt1-RET: Carrier x Noncarrier; Dct-lacZ: Carrier x Carrier (Homozygote x Homozygote)  
Health Report
Gene Details
Promoter No Data  
 1 Symbol No Data  
Symbol name SV40 splicing signal-polyadenylation site, vector sequence  
Chromosome UN  
Common name No Data  
Symbol description No Data  
Promoter mouse Dct promoter  
 2 Symbol lacZ  
Symbol name beta-galactosidase (E. coli)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
Promoter mouse metallothionein-I promoter-enhancer  
 3 Symbol RET  
Symbol name ret proto-oncogene (human)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
References EMBO J. 1991 Nov;10(11):3167-75.
  
Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene.
Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene.
Research applications Cancer Research,
Dermatology Research,
Fluorescent Proteins/lacZ System,
Mouse Models for Human Disease  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Kato, Masashi (Chubu University College of Life and Health Sciences)  Kato, Masashi 
Strain Status /
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