Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
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RBRC No. RBRC06031  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129S2-Kpna1<tm1.2Yyo>  
Former Common name Impa5-  
H-2 Haplotype No Data  
ES cell line D3 [129S2/SvPas]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Tetsuji Moriyama and Yoshihiro Yoneda, Graduate School of Frontier Biosciences, Osaka University in 2006. A neo cassette was removed by crossing with CAG-FLP mice (B6 background), and then exons 2 and 3 were removed by crossing with CAG-Cre mice (B6 background). The mutant mice were backcrossed to C57BL/6 over 10 times.  
Strain description Kpna1 (IPOA5, Impoirtin alpha 5) gene floxed mice. Exons 2 and 3 were flanked by loxP sites.  
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Kpna1  
Symbol name karyopherin (importin) alpha 1  
Chromosome 16  
Common name No Data  
Symbol description No Data  
 2 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 16  
Common name No Data  
Symbol description No Data  
References   
Research applications Cell Biology Research,
Cre/loxP system,
Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
FEBS J., 278, 1561-1572 (2011).
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, the RECIPIENT must contact the DEPOSITOR and notify him the research content. If the DEPOSITOR judges that the research should be a collaborative work, then the RECIPIENT must include the DEPOSITOR/DEVELOPER as co-authors.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Oka, Masahiro (National Institute of Biomedical Innovation)  Oka, Masahiro 
Strain Status /
Availability
(Expected delivery)

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