Strain Data Sheet
Data update: Aug 20, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC06043  
Type Targeted Mutation CongenicCartagena  
Species Mus musculus  
Strain name B6.Cg-Hes3<tm1Kag> Hes5<tm1Kag>  
Former Common name B6-Hes3 KO & Hes5 KO (LacZ knock-in) ; B6-Hes3/Hes5 KO  
H-2 Haplotype No Data  
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]  
Background strain No Data  
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Ryoichiro Kageyama, Institute for Virus Research, Kyoto University in 2000. TT2 ES cells were used. The mutant mice were crossed to C57BL/6 over 6 times.  
Strain description Hes3 and Hes5 double knockout mice. The Hes3 gene was disrupted by a lac-neo cassette. The Hes5 gene was disrupted by IRES-nls-lacZ expression cassette.  
Colony maintenance Hes3: Heterozygote x Wild-type [C57BL/6JJcl]; Hes5: Heterozygote x Wild-type [C57BL/6JJcl]  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Hes3  
Symbol name hairy and enhancer of split 3 (Drosophila)  
Chromosome 4  
Common name No Data  
Symbol description No Data  
 2 Symbol Hes5  
Symbol name hairy and enhancer of split 5 (Drosophila)  
Chromosome 4  
Common name No Data  
Symbol description No Data  
References Development 2004 Nov;131(22):5539-50. Epub 2004 Oct 20.  
Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation.
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Development. 2004 131(22):5539-50.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. The RECIPIENT of BIOLOGICAL resource shall obtain a prior written consent on use of it from the DEPOSITOR Dr. Ryoichiro Kageyama (E-mail: ). (No approval form (Form D) is necessary).  
Additional information
 1 No Data  
Depositor Kageyama, Ryoichiro (Institute for Virus Research, Kyoto University)  Kageyama, Ryoichiro 
Strain Status /
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