Strain Data Sheet
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC06138  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129P2-Serpina12<tm1>  
Former Common name Vaspin KO, B6-Serpina12 KO, Vaspin-/-  
H-2 Haplotype No Data  
ES cell line BK4 [129P2/OlaHsd]  
Background strain No Data  
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Jun Wada, Department of Medicine and Clinical Science, Okayama University and Yoichiro Iwakura, Institute of Medical Sciences, University of Tokyo in 2008. 129P2 derived ES cells were used. The mutant mice were backcrossed to C57BL/6 over 10 times.  
Strain description Vaspin (Serpina12) gene knockout mice. Exon 2 was deleted. Homozygous mutant mice fed with a high-fat-high sucrose diet exhibit increase in body weight, fad pad, liver weight and deterioration of insulin sensitivity.  
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6JJcl]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Serpina12  
Symbol name serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12  
Chromosome 12  
Common name No Data  
Symbol description No Data  
 2 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 12  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 3 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 12  
Common name No Data  
Symbol description No Data  

Research applications Cre/loxP system,
Diabetes and Obesity Research  
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Wada, Jun (Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences)  Wada, Jun 
Strain Status /
(Expected delivery)

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