Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
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RBRC No. RBRC06163  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6;129-Ednrb<tm1Ywa>  
Former Common name ETB/129, B6-Ednra KO  
H-2 Haplotype No Data  
ES cell line JH1 [129S7/SvEvBrd]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Masashi Yanagisawa, The University of Texas Southwestern Medical Center. 129 and C57BL/6 mixed background.  
Strain description ETB (Ednra / endothelin receptor type B) gene knockout mice. A 4.2 kb segment containing exon 3 was replaced with a neomycin resistant gene. Homozygous mutant mice die after birth (average age at death of 25 days).  
Colony maintenance Heterozygote x Wild-type [C57BL/6J(Crlj)]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Ednrb  
Symbol name endothelin receptor type B  
Chromosome 14  
Common name No Data  
Symbol description No Data  
 2 Symbol GH  
Symbol name Growth hormone polyA (Bovine)  
Chromosome 14  
Common name No Data  
Symbol description No Data  
Promoter mouse RNA polymerase II promoter  
 3 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 14  
Common name No Data  
Symbol description No Data  
References Cell. 1994 Dec 30;79(7):1267-76.
  
Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice.
Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice.
Research applications Developmental Biology Research,
Hematological Research,
Mouse Models for Human Disease,
Neurobiology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Cell, 79, 1267-1276 (1994).
Depositor limits the use of the BIOLOGICAL RESOURCE to not-for-profit institutions. Depositor limits the use of the BIOLOGICAL RESOURCE to academic purposes. For-profit institutions and recipients who intend to use BIOLOGICAL RESOURCE for commercial research purposes shall acquire prior written consent from the Depositor. Recipient shall acquire prior written consent from the Depositor prior to filing an application for patent, or intellectual property or other rights based on the results of research using the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Yanagisawa, Masashi (University of Texas Southwestern Medical Center at Dallas)  Yanagisawa, Masashi 
Strain Status /
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