Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
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  Mouse Marking
Figure
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RBRC No. RBRC06240  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129P2-Hmgb1<tm1Ttg>  
Former Common name Hmgb1 cKO, B6-Hmgb1 floxed  
H-2 Haplotype No Data  
ES cell line E14.1 [129P2/OlaHsd]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Hideyuki Yanai and Tadatsugu Taniguchi, Institute of Industrial Science, University of Tokyo and Nobuaki Yoshida, Institute of Medical Science, University of Tokyo in 2011. E14.1 ES cells were used. The mutant mice were backcrossed to C57BL/6.  
Strain description Hmgb1 gene floxed mice. Exons 2 to 4 were flanked by loxP sites. Homozygous mutant mice are viable, but show weak fertility.  
Colony maintenance Heterozygote x Wild-type [or Crossing to C57BL/6JJcl]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Hmgb1  
Symbol name high mobility group box 1  
Chromosome 5  
Common name No Data  
Symbol description No Data  
 2 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 5  
Common name No Data  
Symbol description No Data  
References   
Research applications Cre/loxP system,
Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 Mouse of the Month Jun 2014  
 2 Genotyping protocol <PCR>  
Depositor Taniguchi, Tadatsugu (The University of Tokyo, Graduate School of Medicine)  Taniguchi, Tadatsugu 
Strain Status /
Availability
(Expected delivery)

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