Strain Data Sheet
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Data update: Aug 20, 2019
Health Report   PCR Protocol   Thawing Method
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RBRC No. RBRC06317  
Type Targeted Mutation and TransgeneCartagena  
Species Mus musculus  
Strain name C.Cg-Cables1<Tg(CAG-rtTA,CAG-tTS)138Utr>  
Former Common name TAS, BALB-Cables1/TAS  
H-2 Haplotype No Data  
Background strain BALB/cAJcl  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Fumihiro Sugiyama, Laboratory animal resource center, University of Tsukuba in 2010. The transgene was coinjected into the pronuclei of B6D2F1 fertilized eggs. The transgenic mice were backcrossed to BALB/cAJcl for 14 times.  
Strain description Insertional mutant mice of the Cables1 gene, arose from CAG-rtTA/CAG-tTS transgenic lines. Tg homozygous mice and about 50% of hemizygous mice show agenesis of the corpus callosum (ACC).  
Colony maintenance Carrier x Noncarrier [BALB/cAJcl]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Cables1  
Symbol name CDK5 and Abl enzyme substrate 1  
Chromosome 18  
Common name No Data  
Symbol description No Data  
Promoter CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)  
 2 Symbol rtTA  
Symbol name E. coli Reverse tetracycline transactivator (Mutated tetrepressor DNA-binding domain and the transactivation domain of VP-16)  
Chromosome 18  
Common name E. coli tet repressor (TetR), herpes simplex virus (HSV)VP16 activation domain  
Symbol description No Data  
 3 Symbol tTS  
Symbol name E. coli Tetracycline repressor (tetR), human ZFP KRAB domain cDNA  
Chromosome 18  
Common name No Data  
Symbol description No Data  
References
  

Research applications Developmental Biology Research,
Tet system  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Truncated Cables1 Causes agenesis of the corpus callosum in mice.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Sugiyama, Fumihiro (University of tsukuba)  Sugiyama, Fumihiro 
Strain Status /
Availability
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