Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
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  Mouse Marking
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RBRC No. RBRC06321  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129-Ece2<tm1Ywa>  
Former Common name ECE-2/C57, B6-Ece2 KO  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Masashi Yanagisawa, The University of Texas Southwestern Medical Center. SM1 ES cells were used to generate the mutant mice. The mutant mice were crossed to C57BL/6.  
Strain description ECE-2 (Ece1 / endothelin converting enzyme 2) gene knockout mice. Exon 14 and 15 were replaced with a neomycin resistant cassette.  
Colony maintenance Heterozygote x Wild-type [C57BL/6J(Crlj)]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Ece2  
Symbol name endothelin converting enzyme 2  
Chromosome 16  
Common name No Data  
Symbol description No Data  
 2 Symbol GH  
Symbol name Growth hormone polyA (Bovine)  
Chromosome 16  
Common name No Data  
Symbol description No Data  
Promoter mouse RNA polymerase II promoter  
 3 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 16  
Common name No Data  
Symbol description No Data  
References   
Research applications Developmental Biology Research,
Hematological Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Clin Invest., 105, 1373-1382 (2000).
Depositor limits the use of the BIOLOGICAL RESOURCE to not-for-profit institutions. Depositor limits the use of the BIOLOGICAL RESOURCE to academic purposes. For-profit institutions and recipients who intend to use BIOLOGICAL RESOURCE for commercial research purposes shall acquire prior written consent from the Depositor. Recipient shall acquire prior written consent from the Depositor prior to filing an application for patent, or intellectual property or other rights based on the results of research using the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Yanagisawa, Masashi (University of Texas Southwestern Medical Center at Dallas)  Yanagisawa, Masashi 
Strain Status /
Availability
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