Strain Information | |
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Image | |
BRC No. | RBRC06321 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129-Ece2<tm1Ywa> |
Former Common name | ECE-2/C57, B6-Ece2 KO |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Masashi Yanagisawa, The University of Texas Southwestern Medical Center. SM1 ES cells were used to generate the mutant mice. The mutant mice were crossed to C57BL/6. |
Strain description | ECE-2 (Ece1 / endothelin converting enzyme 2) gene knockout mice. Exon 14 and 15 were replaced with a neomycin resistant cassette. |
Colony maintenance | Heterozygote x Wild-type [C57BL/6J(Crlj)] |
References | J. Clin Invest., 105, 1373-1382 (2000). 10811845 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter GHGrowth hormone polyA (Bovine)16GH Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)16mouse RNA polymerase II promoter |
Ordering Information | |
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Donor DNA | E. coli Neomycin resistance gene, mouse RNA polymerase II promoter, bovine growth hormone polyadenylation site, mouse Ece2 genomic DNA |
Research application | Developmental Biology Research Hematological Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Clin Invest., 105, 1373-1382 (2000).Depositor limits the use of the BIOLOGICAL RESOURCE to not-for-profit institutions. Depositor limits the use of the BIOLOGICAL RESOURCE to academic purposes. For-profit institutions and recipients who intend to use BIOLOGICAL RESOURCE for commercial research purposes shall acquire prior written consent from the Depositor. Recipient shall acquire prior written consent from the Depositor prior to filing an application for patent, or intellectual property or other rights based on the results of research using the BIOLOGICAL RESOURCE. |
Depositor | Masashi Yanagisawa (University of Texas Southwestern Medical Center at Dallas) |
Strain Status | Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |