Strain Information | |
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Image | |
BRC No. | RBRC06322 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.Cg-Edn1<tm1Ywa> |
Former Common name | ET-1 flox (ET1 flox), B6-Edn1 floxed, Endothelin 1(ET-1) conditional knockout without transgene (or Flox ET-1) mouse |
H-2 Haplotype | |
ES Cell line | SM1[129S6/SvEvTac] |
Background strain | |
Appearance | |
Strain development | Developed by Masashi Yanagisawa, The University of Texas Southwestern Medical Center. SM1 ES cells were used to generate the mutant mice. |
Strain description | ET1 (Edn1 / endothelin 1) gene floxed mice. Exon 2 was flanked by loxP sites. |
Colony maintenance | Homozygote x Homozygote [or Crossing to C57BL/6J(Crlj)] |
References | J. Clin. Invest., 114, 4, 504-511 (2004). 10811845 Proc. Natl. Acad. Sci. USA, 101, 2088-2093 (2004). 14764893 Hypertension 56, 121-128 (2010). 20516397 |
Health Report | |
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Examination Date / Room / Rack | 2023/02/06Room:2-検Rack:C 2022/11/07Room:2-検Rack:C 2022/08/08Room:2-検Rack:C |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP13loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP13loxP |
Ordering Information | |
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Donor DNA | phage P1 loxP sites, mouse Edn1 genomic DNA |
Research application | Cre/loxP system Developmental Biology Research Hematological Research Neurobiology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. U S A., 101, 2088-2093 (2004).Depositor limits the use of the BIOLOGICAL RESOURCE to not-for-profit institutions. Depositor limits the use of the BIOLOGICAL RESOURCE to academic purposes. For-profit institutions and recipients who intend to use BIOLOGICAL RESOURCE for commercial research purposes shall acquire prior written consent from the Depositor. Recipient shall acquire prior written consent from the Depositor prior to filing an application for patent, or intellectual property or other rights based on the results of research using the BIOLOGICAL RESOURCE. |
Depositor | Masashi Yanagisawa (University of Texas Southwestern Medical Center at Dallas) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |