Strain Data Sheet
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC06336  
Type Targeted Mutation and Spontaneous Mutation CongenicCartagena  
Species Mus musculus  
Strain name NOD.Cg-Prkdc<scid> E2f1<tm1Meg>  
Former Common name NOD.e2f1<+/->, NOD-scid/E2f1 KO  
H-2 Haplotype No Data  
ES cell line J1 [129S4/SvJae]  
Background strain No Data  
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Hidenobu Senpuku, National Institute of Infectious Diseases. The E2f1<tm1Meg> mice of C57BL/6 and 129 mixed background were backcrossed to NOD/LtJ mice, and furthermore the mutant mice were backcrossed to NOD/SCID mice.  
Strain description E2f1 deficient NOD/SCID mice. Part of exon 3 to exon 4 of E2f1 gene was replaced with a neo cassette. E2f1 homozygous mutant mice are immunodeficiency and show decreased saliva production.  
Colony maintenance E2f1: Heterozygote x Wild-type; scid: Homozygote x Homozygote [or Crossing to NOD/ShiJic-scid/Jcl]  
Health Report
BRC facility Health Report in the last year and a half

Examination Date Room Rack
May 14, 2018 2-検 F
Mar 12, 2018 2-検 F
Jan 15, 2018 2-検 F
Nov 13, 2017 2-検 F
Sep 11, 2017 2-検 F
Jul 10, 2017 2-検 F
May 15, 2017 2-検 F
Mar 13, 2017 2-検 F
Gene Details
Promoter No Data  
 1 Symbol Prkdc  
Symbol name protein kinase, DNA activated, catalytic polypeptide  
Chromosome 16  
Common name No Data  
Symbol description No Data  
 2 Symbol E2f1  
Symbol name E2F transcription factor 1  
Chromosome 2  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 3 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 2  
Common name No Data  
Symbol description No Data  


Research applications Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Exp. Biol. Med. (Maywood)., 234, 1525-1536 (2009).  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Senpuku, Hidenori (National Institute of Infectious Diseases)  Senpuku, Hidenori 
Strain Status /
(Expected delivery)

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