Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
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RBRC No. RBRC06365  
Type Chemically-induced Mutation  
Species Mus musculus  
Strain name B6(D2)-Disc1<Rgsc1393>/Rod  
Former Common name DISC1 RGSC1393 - DISC1-Q31L, B6-Disc1/1393  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Originated from RIKEN ENU-base gene-driven mutagenesis. Established the B6 congenic strains by Tatiana Lipina and John Roder, Mount Sinai Hospital. The mutant mice were backcrossed to C57BL/6 over 15 times (C57BL/6J and C57BL/6NCrl mixed).  
Strain description DISC1 has been reported as a responsible gene for mental illness which was originally found in a large Scottish family with major mental illness such as depression and schizophrenia. Two independently derived ENU-induced mutant mice which have missense mutations in exon 2 of Disc1 gene were developed and analyzed jointly by RIKEN (Japan), University of Edinburgh (UK), and Mount Sinai Hospital (Canada). The mutant mouse with Q31L (Disc1<Rgsc1393>) showed depressive-like behavior with defects, e.g., in the forced swim test. The other mutant mouse with L100P (Disc1<Rgsc1390>) exhibited schizophrenic-like behavior, with profound defect in prepulse inhibition and latent inhibition. These Disc1 missense mutant mice are expected to be very useful as models for depression and schizophrenia. Disc1<Rgsc1390> (L100P)(RBRC06364), Disc1<Rgsc1393> (Q31L)(RBRC06365).  
Colony maintenance Homozygote x Homozygote  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Disc1  
Symbol name disrupted in schizophrenia 1  
Chromosome 8  
Common name No Data  
Symbol description No Data  
References No Data  
Research applications Mouse Models for Human Disease  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Neuron, 54, 387-402 (2007).
The RECIPIENT of for-profit institution must contact the DEPOSITOR separately.
The RECIPIENT of not for-profit institution must contact and discuss in good faith with the DEPOSITOR regarding inventorship, ownership, patent filing and licese fees and others, prior to filing a patent or make a contract with license fees with a third party for invention or products obtained from research results by using the BIOLOGICAL RESOURCES.  
Additional information
 1 No Data  
Depositor RIKEN Genomic Sciences Center   
Strain Status /
Availability
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