Strain Information | |
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Image | |
BRC No. | RBRC06410 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.Cg-Nfkbiz<tm1.1Muta> |
Former Common name | IκB-ζ flox/flox, B6-Nfkbiz floxed |
H-2 Haplotype | |
ES Cell line | Bruce 4 [B6.Cg-Thy1<a>] |
Background strain | |
Appearance | |
Strain development | Developed by Tatsushi Muta, Graduate School of Life Sciences, Tohoku University. Bruce 4 ES cells were used to generate the mutant mice. A frt-neo cassette was removed by crossing with CAG-FLPe (B6) mice. |
Strain description | Nfkbiz gene floxed mice. Exons 5 to 7 were flanked by loxP sites. |
Colony maintenance | Homozygote x Homozygote [or Crossing to C57BL/6JJmsSlc] |
References | Immunity, 38, 450-460 (2013). 23453632 |
Health Report | |
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Examination Date / Room / Rack | 2024/01/09Room:3-BRack:L 2023/10/10Room:3-BRack:L 2023/07/10Room:3-BRack:L 2023/04/10Room:3-BRack:L 2023/03/24Room:3-BRack:L 2023/01/10Room:3-BRack:L 2022/10/11Room:3-BRack:L 2022/07/11Room:3-BRack:L |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Nfkbiznuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta16Nfkbiz<tm1.1Muta>targeted mutation 1.1, Tatsushi Muta Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Frtyeast FRT (flippase recombination target) site16Frt Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP16loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP16loxP |
Ordering Information | |
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Donor DNA | P1 phage loxP sites, yeast FRT (flippase recombination target) site, mouse Nfkbiz genomic DNA |
Research application | Cre/loxP system FLP/frt system |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. |
Depositor | Takashi Maruyama (Gifu University) |
Strain Status | Live mice Frozen embryos Frozen sperm |
Strain Availability | Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) Live mouse (3 to 6 months) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Mouse of the Month Apr 2017 |
BRC mice in Publications |
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Taylor TC, Coleman BM, Arunkumar SP, Dey I, Dillon JT, Ponde NO, Poholek AC, Schwartz DM, McGeachy MJ, Conti HR, Gaffen SL. IκBζ is an essential mediator of immunity to oropharyngeal candidiasis. Cell Host Microbe (2023) 37725983 Kakiuchi N, Yoshida K, Uchino M, Kihara T, Akaki K, Inoue Y, Kawada K, Nagayama S, Yokoyama A, Yamamoto S, Matsuura M, Horimatsu T, Hirano T, Goto N, Takeuchi Y, Ochi Y, Shiozawa Y, Kogure Y, Watatani Y, Fujii Y, Kim SK, Kon A, Kataoka K, Yoshizato T, Nakagawa MM, Yoda A, Nanya Y, Makishima H, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Sugihara E, Sato TA, Maruyama T, Miyoshi H, Taketo MM, Oishi J, Inagaki R, Ueda Y, Okamoto S, Okajima H, Sakai Y, Sakurai T, Haga H, Hirota S, Ikeuchi H, Nakase H, Marusawa H, Chiba T, Takeuchi O, Miyano S, Seno H, Ogawa S. Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis. Nature 577(7789) 260-265(2020) 31853061 Terui H, Yamasaki K, Wada-Irimada M, Onodera-Amagai M, Hatchome N, Mizuashi M, Yamashita R, Kawabe T, Ishii N, Abe T, Asano Y, Aiba S. Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis. Sci Immunol 7(76) eabm9811(2022) 36306369 Murakami T, Takahata Y, Hata K, Ebina K, Hirose K, Ruengsinpinya L, Nakaminami Y, Etani Y, Kobayashi S, Maruyama T, Nakano H, Kaneko T, Toyosawa S, Asahara H, Nishimura R. Semaphorin 4D induces articular cartilage destruction and inflammation in joints by transcriptionally reprogramming chondrocytes. Sci Signal 15(758) eabl5304(2022) 36318619 |