Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
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RBRC No. RBRC06435  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129S2-Lao1<tm1>  
Former Common name LAO1 KO, B6-Lao1 KO  
H-2 Haplotype No Data  
ES cell line D3 [129S2/SvPas]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Kentaro Nagaoka, Graduate School of Agricultural and Life Sciences, University of Tokyo and Masato Ikawa, Research Institute for Microbial Diseases, Osaka University in 2006. D3 ES cells were used to generate the mutant mice. The mice were backcrossed to C57BL/6J.  
Strain description Lao1 gene knockout mice. Exons 1 to 3 were replaced with a neo cassette. Homozygous mutant mice are viable and fertile, but homozygous females exhibit a weak resistance to an intramammary bacterial challenge.  
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6JJcl]  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol No Data  
Symbol name HSV TK Poly(A)  
Chromosome 4  
Common name No Data  
Symbol description No Data  
 2 Symbol Lao1  
Symbol name L-amino acid oxidase 1  
Chromosome 4  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 3 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 4  
Common name No Data  
Symbol description No Data  
References   
Research applications Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
FASEB Journal. 23, 2514-2520 (2009).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
For profit use of the BIOLOGICAL RESOURCE, the RECIPIENT must contact with the Intellectual Property Office.  
Additional information
 1 No Data  
Depositor Nagaoka, Kentaro (Tokyo University Of Agriculture And Technology)  Nagaoka, Kentaro 
Strain Status /
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