Strain Information | |
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Image | |
BRC No. | RBRC06435 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129S2-Lao1<tm1> |
Former Common name | LAO1 KO, B6-Lao1 KO |
H-2 Haplotype | |
ES Cell line | D3 [129S2/SvPas] |
Background strain | |
Appearance | |
Strain development | Developed by Kentaro Nagaoka, Graduate School of Agricultural and Life Sciences, University of Tokyo and Masato Ikawa, Research Institute for Microbial Diseases, Osaka University in 2006. D3 ES cells were used to generate the mutant mice. The mice were backcrossed to C57BL/6J. |
Strain description | Lao1 gene knockout mice. Exons 1 to 3 were replaced with a neo cassette. Homozygous mutant mice are viable and fertile, but homozygous females exhibit a weak resistance to an intramammary bacterial challenge. |
Colony maintenance | Homozygote x Homozygote [or Crossing to C57BL/6JJcl] |
References | FASEB Journal. 23, 2514-2520 (2009). 19276171 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)4mouse phosphoglycerate kinase promoter (PGK promoter) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter HSV TK polyA4 |
Ordering Information | |
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Donor DNA | mouse Phosphoglycerate kinase-1 (PGK) promoter, E.coli neo, HSV TK PolyA, mouse Lao1 genomic DNA |
Research application | Immunology and Inflammation Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. FASEB Journal. 23, 2514-2520 (2009). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. For profit use of the BIOLOGICAL RESOURCE, the RECIPIENT must contact with the Intellectual Property Office. |
Depositor | Kentaro Nagaoka (Tokyo University of Agriculture and Technology) |
Strain Status | Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |