Strain Data Sheet
Data update: Feb 21, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC06467  
Type TransgeneCartagena  
Species Mus musculus  
Strain name C57BL/6-Tg(Prnp-Sirt1,Cryaa-EGFP)1Ksh  
Former Common name PrP-Sirt1 Tg, B6-Prnp-Sirt1/Cryaa-GFP Tg  
H-2 Haplotype No Data  
Background strain No Data  
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Makoto Kinoshita, Nagoya University Graduate School of Science (2008-9). Prnp-Sirt1 and alpha A-crystallin EGFP transcription units were co-injected into the C57BL/6J mouse oocytes.  
Strain description PrP-Sirt1 transgenic mice having a mouse Sirt1 gene under the control of mouse prion gene promoter (MoPrP). The MoPrP-Sirt1 transcription unit was co-injected with a mouse alpha A-crystallin promoter-driven EGFP cDNA.  
Colony maintenance Carrier x Nocarrier [C57BL/6JJmsSlc]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol No Data  
Symbol name SV40 PolyA signal  
Chromosome UN  
Common name No Data  
Symbol description No Data  
Promoter mouse Cryaa promoter  
 2 Symbol EGFP  
Symbol name Enhanced Green Fluorescent Protein, F64L and S65T (Jellyfish)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
Promoter mouse Prnp promoter  
 3 Symbol Sirt1  
Symbol name sirtuin 1  
Chromosome UN  
Common name No Data  
Symbol description No Data  

Research applications Fluorescent Proteins/lacZ System,
Neurobiology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol Brain. 2014 Aug 29;7(1):62. doi: 10.1186/s13041-014-0062-1.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
For profit use of the BIOLOGICAL RESSOURCE, the RECIPIENT must contact with the Intellectual Property Office, Nagoya University to obtain a prior written consent.  
Additional information
 1 GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC's MTA. Please also read Schedule B.  
 2 Mouse of the Month Feb 2015  
Depositor Kinoshita, Makoto (Nagoya University)  Kinoshita, Makoto 
Strain Status /
(Expected delivery)

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