Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC06522  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.Cg-Cthrc1<tm1.1Suna>  
Former Common name Cthrc1 flox, B6-Cthrc1 floxed  
H-2 Haplotype No Data  
ES cell line iTL BA1[(C57BL/6N x 129S6/SvEvTac)F1]  
Background strain C57BL/6JJcl  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Sunao Takeshita, National Center for Geriatrics and Gerontology. (C57BL/6NTac x 129S6/SvEvTac)F1 derived ES cells were used to generate the mutant mice. C57BL/6 background. Floxed mice (RBRC06522): A frt-flanked neo cassette was removed by crossing with CAG-FLPe mice. KO mice (RBRC06523): A frt-flanked neo cassette was removed by crossing with CAG-FLPe mice, and then the exon 2 was removed by crossing with CAG-Cre mice.  
Strain description Cthrc1 gene floxed mice (RBRC06522)(Exon 2 was flanked by loxP sites). Cthrc1 gene KO mice (RBRC06523)(Exon 2 was deleted).  
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6JJcl]  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Cthrc1  
Symbol name collagen triple helix repeat containing 1  
Chromosome 15  
Common name No Data  
Symbol description No Data  
 2 Symbol Frt  
Symbol name yeast FRT (flippase recombination target) site  
Chromosome 15  
Common name No Data  
Symbol description No Data  
 3 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 15  
Common name No Data  
Symbol description No Data  
References   
Research applications Cancer Research,
Cre/loxP system,
FLP/frt system,
Hematological Research,
Metabolism Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Clin. Invest., 123, 3914-3924 (2013).  
Additional information
 1 No Data  
Depositor Ikeda, Kyoji (National Center for Geriatrics and Gerontology)  Ikeda, Kyoji 
Strain Status /
Availability
(Expected delivery)

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