Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jul 19, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
Figure
  Order
RBRC No. RBRC09422  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name FVB.129S6-Gt(ROSA)26Sor<tm1(Pik3ca*E545K)Egan>  
Former Common name R26-Pik3ca(E545K)  
H-2 Haplotype No Data  
Background strain FVB/NJcl  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development W4 mESC were transformed with linearized pROSA-Pik3ca-H1047R or pROSA-Pik3ca-E545K plasmid; this plasmid was built from pBIGT and pROSA gene targeting vectors and contained the mouse Pik3ca cDNA with H1047R or E545K point mutation.  
Strain description Some mice develop blood vessel lesions.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Gt(ROSA)26Sor  
Symbol name gene trap ROSA 26, Philippe Soriano  
Chromosome 6  
Common name No Data  
Symbol description No Data  
 2 Symbol No Data  
Symbol name trimer of the SV40 polyadenylation sequence (tpA)  
Chromosome 6  
Common name No Data  
Symbol description No Data  
 3 Symbol GH  
Symbol name Growth hormone polyA (Bovine)  
Chromosome 6  
Common name No Data  
Symbol description No Data  
 4 Symbol Pik3ca  
Symbol name phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  
Chromosome 6  
Common name No Data  
Symbol description No Data  
 5 Symbol SA  
Symbol name Splice acceptor (adenovirus)  
Chromosome 6  
Common name No Data  
Symbol description No Data  
 6 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 6  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 7 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 6  
Common name No Data  
Symbol description No Data  
References No Data  
Research applications Cancer Research,
Cre/loxP system  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit organization for a not-for-profit research. For use of the BIOLOGICAL RESOURCE by a for-profit organization, the RECIPIENT must prior contact with the developer scientist(Dr. Sean E. Egan, segan@sickkids.ca, Hospital for Sick Children) and must obtain a use license.  
Additional information
 1 No Data  
Depositor Okazaki, Yasuji (Saitama medical school research center for genomic medicine)  Okazaki, Yasuji 
Strain Status /
Availability
(Expected delivery)

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