Strain Data Sheet
Data update: Aug 20, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC09483  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.B6CB-Rnf31<tm1.1Kiwa>  
Former Common name Conditional HOIP delta linear mice, B6.B6CB-Hoip<tm1.1Kiwa>  
H-2 Haplotype No Data  
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]  
Background strain No Data  
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Kazuhiro Iwai, Graduate School of Medicine, Kyoto University. TT2 ES cell line [(C57BL/6 x CBA)F1] was used. A pair of loxP sites were flanking exons encoding a RING-IBR-RING domain. A FRT-flanked Neo resistance gene was deleted. C57BL/6 congenic strain.  
Strain description Floxed mice of the Rnf31 (ring finger protein 31, HOIP) gene. Null mutants at whole body are lethal at embryonic day 10.5.  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Rnf31  
Symbol name ring finger protein 31  
Chromosome 14  
Common name Hoip  
Symbol description No Data  
 2 Symbol Frt  
Symbol name yeast FRT (flippase recombination target) site  
Chromosome 14  
Common name No Data  
Symbol description No Data  
 3 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 14  
Common name No Data  
Symbol description No Data  
References No Data  
Research applications Cre/loxP system,
FLP/frt system  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
EMBO J. 32, 2463-2476 (2013).
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 Mouse of the Month Feb 2016  
 2 Genotyping protocol <PCR>  
Depositor Iwai, Kazuhiro (Kyoto University)  Iwai, Kazuhiro 
Strain Status /
(Expected delivery)

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