Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC09675  
Type TransgeneCartagena  
Species Mus musculus  
Strain name B6.Cg-Tg(Camk2a-Crem)I15Endo  
Former Common name ICER-I-OE  
H-2 Haplotype No Data  
Background strain C57BL/6JJcl  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Shogo Endo and Nobuhiko Kojima, Tokyo Metropolitan Institute of Gerontology. The Camk2a promoter was used to drive brain expression of splice variant I of Crem.A DNA construct was injected to fertilized eggs in B6/C3H/F1 background (RBRC09675) or C57BL6/J background (RBRC09676, RBRC09677). Mice were backcrossed to C57BL/6J.  
Strain description ICER(Inducible cAMP early repressor)-I overexpressing mice under the control of CaMKIIα promoter. No overt change in brain anatomy and general behavior. Impairment in consolidation of fear memory. Attenuation of amygdala kindling.  
Health Report No Data  
Gene Details
Promoter mouse Camk2a promoter  
 1 Symbol Crem  
Symbol name cAMP responsive element modulator  
Chromosome UN  
Common name No Data  
Symbol description No Data  
References No Data  
Research applications Neurobiology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Neurosci., 28, 6459-6472 (2008).
The RECIPIENT must close MTA with Tokyo Metropolitan Institute of Gerontology.  
Additional information
 1 No Data  
Depositor Endou, Syogo (Tokyo Metropolitan Institute of Gerontology)  Endou, Syogo 
Strain Status /
Availability
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