Strain Information | |
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Image | |
BRC No. | RBRC09678 |
Type | Transgene |
Species | Mus musculus |
Strain name | C57BL/6-Tg(Camk2a-Crem)IIEndo |
Former Common name | ICER-II-OE |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6JJcl |
Appearance | |
Strain development | Developed by Shogo Endo and Nobuhiko Kojima, Tokyo Metropolitan Institute of Gerontology. The Camk2a promoter was used to drive brain expression of splice variant II of Crem. A DNA construct was injected to fertilized eggs in C57BL6/J background. Mice were backcrossed to C57BL/6J. |
Strain description | ICER(Inducible cAMP early repressor)-II overexpressing mice under the control of CaMKIIα promoter. No overt change in brain anatomy and general behavior. Impairment in consolidation of fear memory. Attenuation of amygdala kindling. |
Colony maintenance | |
References | J. Neurosci., 28, 6459-6472 (2008). 18562617 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter CremcAMP responsive element modulatorUNCremmouse Camk2a promoter |
Ordering Information | |
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Donor DNA | M Musculus ICER-II cDNA, SV40 polyA signal, M Musculus CaMKIIα promoter, adenovirus tripartite leader sequence +14〜+200, Mus musculus IgG variable region(3'-splice sequence) |
Research application | Neurobiology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci., 28, 6459-6472 (2008).The RECIPIENT must close MTA with Tokyo Metropolitan Institute of Gerontology. |
Depositor | Shogo Endo (Tokyo Metropolitan Institute of Gerontology) |
Strain Status | Frozen embryos |
Strain Availability | Recovery and QC required prior to distribution |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |