Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jul 19, 2019
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RBRC No. RBRC09731  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name ICR.Cg-Braf<tm1.1Tumg>  
Former Common name Braf Q241R/+ ICR (Braf Q241R knock-in mice; ICR background)  
H-2 Haplotype No Data  
ES cell line Bruce 4 [B6.Cg-Thy1]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Yoko Aoki and Shin-ichi Inoue, Tohoku University School of Medicine in 2014. BRUCE-4 ES cells were used. RBRC09730 was crossed with CAG-Cre and then backcrossed to ICR for 11 generations.  
Strain description Braf-mutated protein (BrafQ241R) knock-in mice in ICR genetic background. Q241R mutation in mouse Braf corresponds to Q257R in human BRAF, the most frequent mutation in the cardio-facio-cutaneous (CFC) syndrome. Conditional BrafQ241R knock-in mice are available as RBRC09730.  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Braf  
Symbol name Braf transforming gene  
Chromosome 6  
Common name No Data  
Symbol description No Data  
 2 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 6  
Common name No Data  
Symbol description No Data  
References No Data  
Research applications Cancer Research,
Cell Biology Research,
Cre/loxP system,
Mouse Models for Human Disease  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Human Molecular Genetics, 23, 6553-6566 (2014). Human Molecular Genetics, 24, 7349-7360 (2015).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Aoki, Yoko (Tohoku University)  Aoki, Yoko 
Strain Status /
Availability
(Expected delivery)

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