Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Aug 20, 2019
Health Report   PCR Protocol   Thawing Method
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  Mouse Marking
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RBRC No. RBRC09907  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name 129.Cg-Braf<tm1Tumg>  
Former Common name Braf Q241R Neo/+ (129 background)  
H-2 Haplotype No Data  
ES cell line Bruce 4 [B6.Cg-Thy1]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain description Knock-in mutants in which Braf-mutated protein (BrafQ241R) is expressed in a Cre-dependent manner. Q241R mutation in mouse Braf corresponds to Q257R in human BRAF, the most frequent mutation in the cardio-facio-cutaneous (CFC) syndrome. BrafQ241R heterozygous mice in the ICR genetic background are available as RBRC09731.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol No Data  
Symbol name SV40 polyA signal  
Chromosome 6  
Common name No Data  
Symbol description No Data  
 2 Symbol Braf  
Symbol name Braf transforming gene  
Chromosome 6  
Common name No Data  
Symbol description No Data  
 3 Symbol Frt  
Symbol name yeast FRT (flippase recombination target) site  
Chromosome 6  
Common name No Data  
Symbol description No Data  
 4 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 6  
Common name No Data  
Symbol description No Data  
 5 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 6  
Common name No Data  
Symbol description No Data  
 6 Symbol Tyr  
Symbol name tyrosinase  
Chromosome 7  
Common name No Data  
Symbol description No Data  
 7 Symbol Tyr  
Symbol name tyrosinase  
Chromosome 7  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 8 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 6  
Common name No Data  
Symbol description No Data  
References No Data  
Research applications Cancer Research,
Cre/loxP system,
FLP/frt system  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Hum. Mol. Genet., 23, 6553-6566 (2014).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Aoki, Yoko (Tohoku University)  Aoki, Yoko 
Strain Status /
Availability
(Expected delivery)

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