Strain Data Sheet
Data update: Jul 19, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC10161  
Type TransgeneCartagena  
Species Mus musculus  
Strain name B6;B6D2-Tg(Myh6-Mas1)BChuan  
Former Common name No Data  
H-2 Haplotype No Data  
Background strain No Data  
 1 Appearance No Data  
Genotype No Data  
Strain description The renin-angiotensin system (RAS) plays a pivotal role in the pathogenesis of cardiovascular diseases.
G protein-coupled receptor Mas1 is a receptor for angiotensin (Ang) -(1-7), and ACE2/ Ang-(1-7)/MAS1 receptor axis have been shown to antagonize ACE1/Ang-II/AT1 receptor axis. However, this idea recently looks to become skeptical, and the physiological role of MAS1 in the hearts remains to be determined. C57BL-Tg(alpha-MHC-MAS)A and B overexpress mouse MAS1 gene in cardiomyocytes and die earlier due to heart failure. C57BL-Tg(alpha-MHC-MAS) B mice express MAS1 gene much more highly than A mice, and careful breeding is necessary.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol No Data  
Symbol name Homo sapiens Growh hormone polyA signa  
Chromosome No Data  
Common name No Data  
Symbol description No Data  
Promoter mouse Myh6 promoter  
 2 Symbol Mas1  
Symbol name MAS1 oncogene  
Chromosome UN  
Common name No Data  
Symbol description No Data  
References No Data  
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to use the BIOLOGICAL RESOURSE only for publication of research papers. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
Depositor Iwamoto, Takashi (Chubu University)  Iwamoto, Takashi 
Strain Status /
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