Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
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RBRC No. RBRC10391  
Type Targeted Mutation CongenicCartagena  
Species Mus musculus  
Strain name C.Cg-Xcr1<tm2(HBEGF/Venus)Ksho>  
Former Common name No Data  
H-2 Haplotype No Data  
ES cell line Bruce 4 [B6.Cg-Thy1]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Tsuneyasu Kaisho, Research Center for Allergy and Immunologuy, RIKEN around 2008. BALB/c congenic line. C57BL/6 congenic strain is available as RBRC09485.  
Strain description A chemokine receptor, XCR1, is a receptor for XCL1 and expressed dominantly in one dendritic cell subset. XCR1-DTRvenus mice were generated by knocking the gene encoding a fusion protein consisting of human diphtheria toxin receptor (DTR or HBEGF) and a fluorescence protein, venus (derived from Dr. Atsushi Miyawaki at BRI) into the murine XCR1 gene locus. In XCR1-DTRvenus mice, XCR1-expressing cells can be detected by venus expression and ablated transiently by the administration of diphteria toxin.  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Frt  
Symbol name yeast FRT (flippase recombination target) site  
Chromosome 9  
Common name No Data  
Symbol description No Data  
 2 Symbol HBEGF  
Symbol name heparin-binding EGF-like growth factor (human)  
Chromosome 9  
Common name No Data  
Symbol description No Data  
 3 Symbol Venus  
Symbol name Green Fluorescent Protein, F46L (Jellyfish)  
Chromosome 9  
Common name No Data  
Symbol description No Data  
 4 Symbol Xcr1  
Symbol name chemokine (C motif) receptor 1  
Chromosome 9  
Common name No Data  
Symbol description No Data  
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)  
 5 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 9  
Common name No Data  
Symbol description No Data  
References No Data  
Research applications FLP/frt system,
Fluorescent Proteins/lacZ System,
Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
1. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form (form D).
2. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.J. Immunol., 190, 6071-6082 (2013).
3. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit organization for a not-for-profit research. For use of the BIOLOGICAL RESOURCE by a for-profit organization, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.
4. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER of the Venus using Approval form (form V) (Lab Contact: Laboratory for Cell Function Dynamics, RIKEN CBS: sakurai-h@brain.riken.jp).  
Additional information
 1 Approval form Form V (English)  
Depositor Kaisho, Tsuneyasu (RIKEN Center for Integrative Medical Sciences (IMS))  Kaisho, Tsuneyasu 
Strain Status /
Availability
(Expected delivery)

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