Strain Information | |
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Image | |
BRC No. | RBRC10468 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129-Scn2a<tm2.1Kzy> |
Former Common name | Scn2a-floxed, Scn2afl/+ |
H-2 Haplotype | |
ES Cell line | E14 [129P2/OlaHsd] |
Background strain | |
Appearance | |
Strain development | Developed by Ikuo Ogiwara and Kazuhiro Yamakawa, RIKEN BSI in 2010. E14 ES cells(129P2/OlaHsd) were used and the Neo gene was deleted by CAG-Flpe mice. C57BL/6J congenic line (24 generations). |
Strain description | Scn2a (sodium channel, voltage-gated, type II, alpha) floxed mice. Exon 2 is flanked by a pair of loxP. |
Colony maintenance | |
References | Commun. Biol., 1, Article number: 96 (2018). 30175250 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Scn2asodium channel, voltage-gated, type II, alpha2Scn2a<tm2.1Kzy>targeted mutation 2.1, Kazuhiro YamakawaScn2a1 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Frtyeast FRT (flippase recombination target) site2Frt Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP2loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP2loxP |
Ordering Information | |
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Donor DNA | phage P1 loxP sites, yeast FRT (flippase recombination target) site, mouse Scn2a genomic DNA |
Research application | Cre/loxP system FLP/frt system |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Ogiwara, et al., (2018) Communications Biology volume 1, Article number: 96. https://doi.org/10.1038/s42003-018-0099-2.In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Kazuhiro Yamakawa (RIKEN) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |