Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC10756  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129-Mab21l1<tm1Nao>  
Former Common name C57BL/6(Mab21l1tm1Nao), Mab21l1tm1Nao  
H-2 Haplotype No Data  
ES cell line R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development R1 ES cells were established in August 1991 from a male blastocyst hybrid of two 129 substrains (129X1/SvJ and 129S1/SV-+p+Tyr-c Kitl Sl-J/+).
abnormal male preputial gland morphology
abnormal eye morphology
abnormal skull development  
Strain description This gene is similar to the MAB-21 cell fate-determining gene found in C. elegans. It may be involved in eye and cerebellum development.
Mutation details: The entire gene coding region was replaced with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutants was confirmed by whole mount in situ hybridization analysis of E10.5 homozygous mutant embryos.  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol No Data  
Symbol name SV40 polyA  
Chromosome 3  
Common name No Data  
Symbol description No Data  
 2 Symbol Mab21l1  
Symbol name mab-21-like 1  
Chromosome 3  
Common name No Data  
Symbol description No Data  
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)  
 3 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 3  
Common name No Data  
Symbol description No Data  
References No Data  
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.  
Additional information
 1 No Data  
Depositor Takahashi, Naoki (The University of Tokyo)  Takahashi, Naoki 
Strain Status /
Availability
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