Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Apr 19, 2019
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RBRC No. RBRC00361  
Type Targeted Mutation CongenicCartagena   8wks,♂
Species Mus musculus  
Strain name C57BL/6-TgH(p38)/118  
Former Common name No Data  
H-2 Haplotype No Data  
ES cell line R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]  
Donor strain (129X1/SvJ x 129S1/Sv)F1-Kitl+ via R1 ES cell line  
Background strain C57BL/6J  
Appearance
 1 Appearance black  
Genotype a/a  
Strain development This B6 congenic strain was created by Dr. Sudo T to obtain
p38alpha-deficient mice with standard and stable genetic background. The mice have been successively backcrossed to C57BL/6JJcl strain for 14 generations (N14) at the animal facility of RIKEN Tsukuba Institute.  
Strain description Activity of the p38alpha MAP kinase is stimulated by various stresses and hematopoietic growth factors. This strain was created to investigate the role of p38alpha in mouse development and physiology (Tamura et al. 200). Some p38alpha (-/-) embryos die between embryonic days 11.5 and 12.5, those that develop past this stage have normal morphology but are anemic owing to failed definitive erythropoiesis, caused by diminished erythropoietin (Epo) gene expression.  
Colony maintenance The mice have been successively backcrossed to C57BL/6JJcl strain for 14 generations (N14).  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Mapk14  
Symbol name mitogen activated protein kinase 14  
Chromosome 17  
Common name Crk1, Csbp1, CSBP2, Mxi2, p38, p38 MAP Kinase, p38-alpha, PRKM14, PRKM15; p38 alpha MAP kinase  
Symbol description No Data  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 17  
Common name neo; neomycin;  
Symbol description No Data  
References Cell. 2000 Jul 21;102(2):221-31.
J Biol Chem. 2002 Oct 4;277(40):37896-903. Epub 2002 Jul 22.  


Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers.
The DEPOSITOR should be a co-author in articles when the users publish their data using these mice for 2 year after provided to the RIKEN BRC.
The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Sudo, Tatsuhiko (RIKEN Discovery Research Institute)  Sudo, Tatsuhiko 
Strain Status /
Availability
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