Strain Data Sheet
Data update: Apr 19, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC01507  
Type Targeted MutationCartagena   wks
Species Mus musculus  
Strain name B6.Cg-Olig2<tm1(cre/Esr1*)Htak>/Rbrc  
Former Common name Olig2-CreER knock in mouse  
H-2 Haplotype No Data  
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]  
Donor strain (C57BL/6 x CBA)F1 via TT2 ES cell line  
Background strain No Data  
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Dr. Hirohide Takebayashi at Kyoto Universtiy in 2002. A cassette containing neo and tamoxifen-inducible cre genes was inserted into the exon 2 encoding the basic helix-loop-helix domain. The mutant mice were backcrossed to C57BL/6N.  
Strain description B6.Cg-Olig2<tm1(cre/Esr1)Htak>. These knock-in mice have a tamoxifen-inducible cre (cre-ER<TM>) at the Olig2 locus. Cre-ER<TM> is expressed in motoneuron and oligodendrocyte progenitors.  
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6NCrj)
Homozygous mutant mice die postnatally.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Olig2  
Symbol name oligodendrocyte transcription factor 2  
Chromosome 16  
Common name Bhlhb1, Olg-2, RK17  
Symbol description No Data  
 2 Symbol Esr  
Symbol name estrogen receptor 1 (ER)  
Chromosome 16  
Common name tamoxifen-inducible  
Symbol description No Data  
 3 Symbol cre  
Symbol name Phage P1 Cre recombinase  
Chromosome 16  
Common name No Data  
Symbol description No Data  
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)  
 4 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 16  
Common name neo; neomycin;  
Symbol description No Data  
References Curr Biol. 2002 Jul 9;12(13):1157-63.
Dev Biol. 2006 May 15;293(2):358-69. Epub 2006 Apr 3.  
The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages.
The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages.
Research applications Cell Biology Research,
Cre/loxP system,
Neurobiology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Current Biology, 12, 1157-1163 (2002).
The RECIPIENT should contact the DEPOSITOR in the case of application for patent or commercial use with the results from the use of the BIOLOGICAL RESOURCE. Within the first 2 years after deposition by the DEPOSITOR to the RIKEN BRC, the RECIPIENT should consult DEPOSITOR in regard to co-authorship of the DEPOSITOR/DEVELOPER in publication(s) resulted by the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 Mouse of the Month July 2006
Breeding characters  
 2 Genotyping protocol <PCR>  
Depositor Takebayashi, Hirohide (National Institutes of Natural Sciences)  Takebayashi, Hirohide 
Strain Status /
(Expected delivery)

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