Strain Information | |
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Image | |
BRC No. | RBRC10243 |
Type | Targeted Mutation Congenic |
Species | Mus musculus |
Strain name | B6.129-Scn2a<tm1Mml> |
Former Common name | |
H-2 Haplotype | |
ES Cell line | R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>] |
Background strain | |
Appearance | |
Strain development | Developed by Prof. Maurice Montal, Section of Neurobiology, Division of Biological Sciences, University of California San Diego, USA. Deposited by Kazuhiro Yamakawa, RIKEN BSI in 2018. R1 ES cells[(129X1/SvJ x 129S1/Sv)F1] were used. C57BL/6J congenic line. |
Strain description | Scn2a (sodium channel, voltage-gated, type II, alpha)knockout mice. Homozygous mutants are lethal at postnatal day 1 or 2. Heterozygotes are fertile. |
Colony maintenance | |
References | Biophys. J., 78(6), 2878-2891 (2000). 10827969 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Scn2asodium channel, voltage-gated, type II, alpha2Scn2a<tm1Mml>targeted mutation 1, Mauricio MontalScn2a1 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)2herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Ordering Information | |
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Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E.coli neo, mouse Scn2a genomic DNA |
Research application | |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Biophys. J., 78(6), 2878-2891 (2000).Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEVELOPER (Prof. Maurice Montal, Section of Neurobiology, Division of Biological Sciences, University of California San Diego, USA, E-mail: mmontal@ucsd.edu) using the Approval Form. 2) The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. The RECIPIENT must contact the DEVELOPER (Prof. Maurice Montal) in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Kazuhiro Yamakawa (RIKEN) |
Strain Status | Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |