Strain Information | |
---|---|
Image | |
BRC No. | RBRC10762 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.B6CB-Gsdmd<tm1.2Tshir>/Ms |
Former Common name | Gsdmdflox/flox, Gsdmdfl/fl, Gsdmd cKO |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | |
Appearance | |
Strain development | Developed by Toshihiko Shiroishi and Tomoaki Fujii, National Institute of Genetics in 2005. TT2 ES cells derived from (C57BL/6 x CBA)F1 were used. Mice were backcrossed to C57BL/6J for more than 10 generations. C57BL/6 congenic line. Frt-flanked Neo cassette was deleted by crossing with Flp mice. |
Strain description | Floxed mice for Gsdmd. |
Colony maintenance | |
References | Carcinogenesis, 44(4):341-349 (2023). 36753047 Genesis, 46, 418-423 (2008). 18693275 |
Health Report | |
---|---|
Examination Date / Room / Rack | 2024/02/26Room:4-CRack:E 2023/11/27Room:4-CRack:E 2023/08/28Room:4-CRack:E 2023/05/29Room:4-CRack:E 2023/02/27Room:4-CRack:E 2022/11/29Room:4-CRack:E 2022/08/29Room:4-CRack:E 2022/05/31Room:4-CRack:E |
Gene | |
---|---|
Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Frtyeast FRT (flippase recombination target) site15Frt Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP15loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP15loxP |
Ordering Information | |
---|---|
Donor DNA | P1 bacteriophage loxP sites, S. cerevisiae Frt site, mouse Gsdmd genomic DNA |
Research application | Cre/loxP system FLP/frt system Immunology and Inflammation Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genesis, 46, 418-423 (2008).The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. (Contact info: Tsuyoshi Koide, Ph.D. <tkoide@nig.ac.jp>, Mouse Genomics Resource Laboratory) |
Depositor | Toshihiko Shiroishi (National Institute of Genetics) |
Strain Status | Live mice Frozen embryos Frozen sperm |
Strain Availability | Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) Live mouse (1 to 3 months) |
Additional Info. | Mouse of the Month Mar 2020 Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
---|
No Data |